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Journal of Korean Institute of Fire Science and Engineering 2002;16(3):12-15.
Published online September 30, 2002.
연립 주택 화재시 유독가스 방출 특성과 Rats를 이용한 독성평가
김홍, 강영구, 김동현, 정기창, 이창섭, 김운형
1호서대학교 환경안전공학부2호서대학교 환경안전공학부3단국대학교병원 산업의학과4호서대학교 환경안전공학부5경기도 소방학교6경민대학 소방과학과
Toxicity Evaluation of Effluent Gases from a Residental Fire by Rats
Kim Hong, Kang Young-Goo, Kim Dong-Hyun, Jung Ki-Chang, Lee Chang-Seop, Kim Woon-Hyung
요약
화재에 의한 독성가스의 노출은 인간에게 있어서 화재시 생명에 아주 위험한 요소일 것이다. 다양한 화재에 의한 독성가스의 노출 중 본 논문에서는 경기도 안산시 재개발지구에서 한 연립주택을 이용하여 실재화재와 같은 조건으로 화재 시험을 하였다. 화재시 발생하는 가스 CO, $CO_2$, $O_2$, $SO_2$, NO 및 $NO_2$등을 측정하였으며, 발생하는 가스를 실험동물인 백서(S.D.)에 노출시켜 2분 간격으로 혈액을 체취 하였다. 독성 평가를 위하여 백서의 혈액과 혈청 중 Glucose, AST(GOT), ALT(GPT), CBC Count 및 CO(carboxy)-Hb를 분석하였다. 폭로되는 CO의 농도와 백서의 혈액중 CO-Hb 농도사이에 양-반응 관계(dose-response relationship)를 보였다.
Abstract
It has long been recognized that exposure to fire-induced toxic gases is a fatal hazard confront-ing people in fires. In this study, an indoor fire experiment was conducted in an unoccupied residential building located in An-san city, Kyoung-gi province, and the composition of effluent gases, which include CO, $CO_2$, $O_2$, $SO_2$, NO and $NO_2$, were measured by a gas analyzer. A group of lab rats were exposed to the toxic gases released from fire, and the blood samples of the rats were gathered every 2 minutes. A toxicity evaluation was conducted by analyzing the concentrations of Glucose, AST(GOT), ALT(GPT), CBC Count and CO(carboxy)-Hb in the blood samples. Shown from the analysis is the does-response relationship between the CO concentration that rats were exposed to and the CO-Hb concentration in rat blood.
Key Words: Toxicity, Residential fire, Exposed, Blood and Serum, CO(carboxy)-Hb
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